Negative correlation between ACE2 gene expression levels and loss of taste in a cohort of COVID-19 hospitalized patients: New clues to long-term cognitive disordersArticle Published on 2022-09-292022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 유전자 메커니즘, [키워드] ACE1 ACE2 ACE2 expression ACE2 gene addition Ageusia Alu Analysis Angiotensin-converting enzyme Anosmia association Brain Cell cells cognitive Cognitive dysfunction Cohort consequence correlation COVID-19 disorder Effect evaluated expression expression level Factors gene expression level Genetic genetic association Health Hospitalized hospitalized patients human cell initial symptoms long-COVID long-COVID syndrome Loss of Smell loss of taste molecular nasopharyngeal negative New obligatory occur Olfactory epithelium outcomes penetration polymorphism prevalent priming protease Quantitative quantitative trait receptor Regression model Research Respiratory system RT-qPCR SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe COVID-19. Spread Symptom Symptoms tissue TMPRSS2 variable virus [DOI] 10.3389/fcimb.2022.905757 PMC 바로가기
Genome-wide association study of SARS-CoV-2 infection in Chinese population중국 인구의 SARS-CoV-2 감염에 대한 게놈 차원의 연관성 연구Article Published on 2022-09-012022-09-11 Journal: European Journal of Clinical Microbiology & Infect [Category] MERS, SARS, 변종, 진단, [키워드] analyzed ANKRD27 association Asymptomatic carried CD200R1L Chinese close contact conducted coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 severity ERAP1 Exome Genetic genetic association genetic variability Genetic variant genetic variants Genome sequencing Genome-wide association study global public health GWAS heterogeneous individual LINC00700 loci locus MAN1A2 molecular NEIL3 pathogenesis of COVID-19 Patient PCNX2 PLCL2 POLR2A Polymorphisms positive provided recruited SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 Sequencing severity single-nucleotide Single-nucleotide polymorphisms suggested susceptibility Susceptibility. symptomatic patient tested therapeutic options ZMAT3 [DOI] 10.1007/s10096-022-04478-5 PMC 바로가기 [Article Type] Article
ABO blood group and link to COVID-19: A comprehensive review of the reported associations and their possible underlying mechanismsABO 혈액형 및 COVID-19와의 연관성: 보고된 연관성 및 가능한 기본 메커니즘에 대한 포괄적인 검토Review Published on 2022-08-012022-09-11 Journal: Microbial pathogenesis [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ABO ABO antibodies ABO blood Group system ABO blood type ABO blood types Affect antibodies Antigen association associations Blood Blood Group blood group system blood type cells COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients COVID-19 severity described Disease progression disease severity disease transmission Diseases explain facilitate genetic association genetic associations glycobiology glycoprotein group higher risk Host hypothese implication Infectious diseases Interaction locus lower risk management mechanism Mortality natural history outcome outcomes progression protective effect protective factor reported risk risk factor risk of infection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2. severity Structure susceptibility the disease thromboembolic Thromboembolic event Thromboembolic events Transmission transmitted with COVID-19 [DOI] 10.1016/j.micpath.2022.105658 PMC 바로가기 [Article Type] Review
Genetic variants in the NF-κB signaling pathway (NFKB1, NFKBIA, NFKBIZ) and risk of critical outcome among COVID-19 patientsNF-κB 신호 전달 경로(NFKB1, NFKBIA, NFKBIZ)의 유전적 변이와 COVID-19 환자의 중대한 결과 위험Article Published on 2022-08-012022-09-11 Journal: Human immunology [Category] COVID19(2023년), SARS, 변종, [키워드] Cohort component Control COVID-19 COVID-19 patient Critical D-dimer value Deceased explain form Gene polymorphisms genetic association Genetic variation Genotype healthy Homozygosis hyperinflammatory state ICU ICU admission implicated Inflammation insertion lower expression mice Mortality NF-κB NF-κB signaling NF-κB signaling pathway NFkB1 NFKBIA NFKBIZ NFKBIZ. outcome pathway Patient patients populations predisposition RATs Respiratory Support risk risk of death SARS-COV-2 infection Sepsis severe COVID-19 severe forms of COVID-19 significant effect Spanish patient Survivors the patient total blood transcript variant variants viral disease was increased [DOI] 10.1016/j.humimm.2022.06.002 PMC 바로가기 [Article Type] Article
High-affinity FcγRIIIa genetic variants and potent NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC) responses contributing to severe COVID-19고친화성 FcγRIIIa 유전적 변이체와 강력한 NK 세포 매개 항체 의존성 세포독성(ADCC) 반응이 심각한 COVID-19에 기여Article Published on 2022-07-012022-09-11 Journal: Genetics in medicine : official journal of the Ame [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] activating Activation ADCC ADCC assay antibody antibody-dependent cellular cytotoxicity approach association cell receptor cell receptors cellular cytotoxicity contribute contributing to COVID-19 COVID-19 severity Deceased disease severity Evidence experiments expressing expression FCGR3A FcγRIIIa functional Genetic genetic association Genetic variant genetic variants hallmark Hospitalized hospitalized patient hospitalized patients Immunopathogenesis in vitro investigated limit Mild natural killer NK cell NK cells occur Patient patients with COVID-19 proinflammatory provide receptor response resulting SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 infections Sequence variant. severe COVID-19 severity of COVID-19 significantly significantly higher subsequent variant with COVID-19 [DOI] 10.1016/j.gim.2022.04.005 PMC 바로가기 [Article Type] Article
Severe COVID-19-associated variants linked to chemokine receptor gene control in monocytes and macrophages단핵구 및 대식세포의 케모카인 수용체 유전자 조절과 관련된 심각한 COVID-19 관련 변이체Article Published on 2022-04-142022-09-11 Journal: Genome Biology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] 3D genome organization 3p21.31 association CCR1 CCR2 CCR5 Chemokine receptor chromatin Control COVID-19 CTCF elevated epigenomic Gene regulation Genes Genetic genetic association Genome Genome-wide association studies GWAS hallmark Hospitalization increased expression infiltration inflammatory monocyte inflammatory monocytes locus Macrophage macrophages mechanism monocyte Monocytes organ rationale Regulatory regulatory element risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2. severe COVID-19 SNP variant [DOI] 10.1186/s13059-022-02669-z PMC 바로가기 [Article Type] Article
A year of COVID-19 GWAS results from the GRASP portal reveals potential genetic risk factorsResearch article Published on 2022-04-012022-10-05 Journal: Human Genetics and Genomics Advances [Category] 유전자 메커니즘, [키워드] ABO analyses ApoE applied approach Blood Group carriers coronavirus disease COVID-19 COVID-19 phenotypes COVID-19 susceptibility death decrease develop Diseases DPP9 exhibiting genetic association genetic mechanism genetic risk factor Genetic variant genetics Genome-wide association study GWAS help Hospitalization increase in increased risk independent independent datasets Infection involved loci locus LRMDA MAPT modulating MUC4 Odds ratio outcome performed phenotype Previous studies Release released replicate reveal RPL24 severity stratified by sex susceptibility therapeutic strategy trajectory UK biobank variant women [DOI] 10.1016/j.xhgg.2022.100095 [Article Type] Research article
Expanded COVID-19 phenotype definitions reveal distinct patterns of genetic association and protective effects Research Published on 2022-04-012022-10-05 Journal: Nature Genetics [Category] 유전자 메커니즘, 진단, [키워드] aggregate Analysis association clinical manifestation collected complement coronavirus disease COVID-19 COVID-19 phenotype defined eight Genetic genetic association genetic component Genome-wide association study genome-wide significant GWASs loci Meta-analysis Mild Multiple outcome Participants performed phenotype Phenotypes Protective protective effect replication analysis reported Research risk severity susceptibility symptom severity therapeutic target These data [DOI] 10.1038/s41588-022-01042-x [Article Type] Research
Genetic association of IL17 and the importance of ABO blood group antigens in saliva to COVID-19IL17의 유전적 연관성과 코로나19에 대한 타액 내 ABO 혈액형 항원의 중요성Article Published on 2022-03-092022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘, 치료기술, [키워드] ABO Activation Analysis Antigen association Blood Group carried caused conducted COVID-19 COVID-19 patient determine Factor FOXP4 FOXP4-AS1 FUT2 General population Genetic genetic association genetic factors genetics genome-wide association Genome-wide association study Genomic analysis Genotype GWAS identify IFNAR2 IL17 IL17A IL17F individual infection with SARS-CoV-2 innate immune response International involved Japan Japanese Meta-analysis mRNA expression nine outbreak Patient presenting replicated reported Respiratory failure risk allele Risk factors Saliva SARS-COV-2 infection SARS-CoV-2 virus severe COVID-19 severity severity of COVID-19 significantly significantly lower SNP virus worldwide pandemic [DOI] 10.1038/s41598-022-07856-3 PMC 바로가기 [Article Type] Article
Systematic review of host genetic association with Covid-19 prognosis and susceptibility: What have we learned in 2020?Covid-19 예후 및 감수성과 숙주 유전적 연관성에 대한 체계적인 검토: 2020년에 우리는 무엇을 배웠습니까?Review Published on 2022-03-012022-09-11 Journal: Reviews in Medical Virology [Category] SARS, 변종, [키워드] ABO ACE1 ACE2 analyzed ApoE association associations available data candidate candidate gene candidate genetic variants claimed clinical manifestation complex interaction COVID-19 COVID-19 prognosis COVID-19 severity database disease Effects eligible environmental factors evaluated examined Exome exome sequencing FIVE furin Genes Genetic genetic association Genetic association studies genetic variants GWAS Health healthcare heterogeneous HLA Host IFITM3 IFNL3 IFNL4 IMPROVE indicated Infection locus Meta-analysis moderate outcome outcomes pathophysiology performed Polymorphisms predict Prognosis recommendations reduce replicate Replication reported Research SARS-CoV-2 SARS-COV-2 infection Sequencing severity susceptibility Susceptibility. TMPRSS2 whole-genome [DOI] 10.1002/rmv.2283 PMC 바로가기 [Article Type] Review